( Derrien et al., 2012 Zhao et al., 2021) Most lncRNAs are transcribed by RNA polymerase II, and then are capped at the 5′ end, ploy A tail added at the 3′ end, and edited to form biologically functional lncRNAs. Long non-coding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides and comprise the main category of non-coding RNAs ( Palazzo and Koonin, 2020) According to the latest release of the database NONCODE, the number of human lncRNAs is approximately 170,000, which is much larger than that of protein-coding RNAs. ( Barik et al., 2021) Although traditionally most research about these processes has focused on the role of protein-coding RNAs ( Slack and Chinnaiyan, 2019), recent efforts have focused on non-coding RNAs, which are now known to be regulatory molecules that mediate cellular processes and play an important role in tumorigenesis and cancer development. However, several cancer complications such as tumor metastasis, drug resistance, and cancer recurrence hinder the management of this disease and contribute to the high mortality associated with it. ( Sung et al., 2021) In recent years, the life expectancy of patients with cancer has greatly increased owing to the earlier detection and appropriate therapies. In this review, we introduce the biologic functions of lncRNAs and describe the molecular mechanism and clinical significance of LINC00467 in detail.Ĭancer, with high morbidity and mortality, has long been known as a primary life-threatening disease worldwide and imposes a huge economic and social burden on every country. The present evidence suggests that LINC00467 may serve as a promising prognostic indicator and become a novel cancer therapeutic target. Moreover, overexpressed LINC00467 was associated with a poor clinical prognosis. Functional experiments of LINC00467 revealed that LINC00467 overexpression enhanced cell chemoresistance, proliferation, migration, and invasion in several types of cancers. Long intergenic non-coding RNA 467 (LINC00467) is an upregulated lncRNA in diverse diseases, especially in several types of cancers. Long noncoding RNAs (lncRNAs) have been widely demonstrated to participate in the genomic activities of various human cancers. Intricate genetic mutations promote the progression of different cancer types. Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.Di Wu †, Rongfei Li †, Jingyu Liu, Changcheng Zhou and Ruipeng Jia*
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